KNOSYS

KNOSYS Users

KNOSYS behavior systems have been installed at commercial and non-profit research institutes and universities in a number of countries. We work closely with individual investigators to insure that the system selected will meet their needs. KNOSYS offers on-site installation and training in the use of our equipment and software routines.

Installation Sites:

Korea:
Samsung Medical Center (Seoul)

Australia:
Sydney University (Sydney)
University of New South Wales (Sydney);
La Trobe University (Bundoora)

England:
Cambridge University;
Cerebrus Ltd. (London);
University College London

Austria
University of Vienna (Vienna)

Denmark
Aarhus University (Aarhus)

Belgium
University of Liege (Liege)

France:
Institut Pasteur (Paris)
Ecole Pratique des Hautes Etudes (Montpellier)
Institut Francois Magendie (INSERM, Bordeaux).
Unité INSERM, Nantes

Germany:
University of Tubingen (Tubingen)
Max Planck Inst. Medical Research (Heidelberg)
Max Planck institute of Biophysics (Frankfurt)
Medical Faculty, LMU (Munich)

Sweden:
Umea University (Umea)
Linköpings Universitet (Linkopings)

Switzerland:
Ecole Polytechnique Fédérale de Lausanne (EPFL) (Lausanne)

Israel:
Weizmann Inst. Science (Rehovot)
Haifa University (Haifa)

Canada:
McGill University (Montreal)
Dalhousie University (Halifax)

Japan:
University of Tokyo (Tokyo)
RIKEN (Saitama)

United States:
University of South Florida (Tampa); University of Pennsylvania School of Medicine (Philadelphia);Monell Chemical Senses Center (Philadelphia); University of California (UCLA, Irvine and Davis); Duke University (Durham); Regis University (Denver); University of Colorado School of Medicine (Denver); University of Utah (SLC); University of Maryland School of Medicine (Baltimore); US Army (AMCAC, Natick); Walter Reed Institute of Research (Bethesda); Columbia University (New York); NIH (Bethesda); Fred Hutchinson Cancer Research Center (Seattle): University of Kentucky School of Medicine (Lexington); University of Florida (Gainesville); Boston University (Boston); Yale University (New Haven); Carnegie Mellon University (Pittsburgh); Randolph-Macon College (Ashland); University of Vermont (Burlington), Lovelace Respiratory Research Institute, Albuquerque; Harvard University (Cambridge).



Some recent papers (2000 – 2008) in which Knosys Olfactometer instruments have been used or described.


Schellinck HM, Brown RE. 2000 Selective depletion of bacteria alters but does not eliminate odors of individuality in Rattus norvegicus. Physiol. and Behav., 70:261-270.

Slotnick, B. et al. Can rats acquire an olfactory learning set? 2000. J. Experimental Psychology: Animal Behavior Processes, 26:399-415.

Bodyak, N. and Slotnick, B. 2000 Performance of mice in an automated olfactometer: Odor detection, discrimination and odor memory. Chem Senses, 24:637-645

Slotnick, B. et al. 2000 Does intranasal application of zinc sulfate produce anosmia in the rat? Behavioral Neuroscience, 2000, 114:814-829.

Rubin BD and Katz LC. 2001 Spatial coding of enantiomers in the rat olfactory bulb. Nature Neuroscience, 4r:355-356

Slotnick, B. Animal cognition and the rat olfactory system. 2001 Trends in Cognitive Sciences, 5: 216-222.

Greiner, R.S. et al.. 2001 Olfactory discrimination deficits in N-3 fatty acid deficient rats. Physiology and Behavior,72:379-85.

Catalan, J. et al. 2002. Cognitive deficits in docosahexaenoic acid deficient rats. Behavioral Neuroscience, 116:1022-1031.

Slotnick, B. and Bodyak, N. 2002 Odor discrimination and odor quality perception in rats with disruptions of connections between the olfactory epithelium and the olfactory bulb. J. Neuroscience. 22:4205-4216.

Stapleton, J.R. et al. 2002 Discrimination between the tastes of sucrose and monosodium glutamate in rats. Chem. Senses 27:375-382.

Slotnick, B. and Schellinck, H. 2002 Methods in olfactory research with rodents. In: Frontiers and Methods in Chemosenses, (Simon, S.A. and Nicolelis, M., eds). CRC Press,. pp 21-61.

Bisulco, S and Slotnick, B. 2003 Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs.
Chem Senses 28:361-370.

Kelliher, K.R. et al. 2003. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Proc Natl Acad Sci U S A. 100:4299-42304.

Kirner, A. et al. 2003 Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D- and L-carvone. Behav Brain Res.,138:201-206.

Slotnick, B. and Bisulco, S. 2003 Detection and discrimination of carvone enantiomers in rats with olfactory bulb lesions. Neuroscience, 121:451-457.

Villemur, C., et al. 2003 Effects of odors on pain perception: Deciphering the roles of emotion and attention. Pain 2003, 106:101-108.

McBride, K, et al. 2003 Does intranasal application of zinc sulfate produce anosmia in the mouse? Chemical Senses, 28:659-670.

Doty,RL, et al.. 2003 No Influence of Scopolamine Hydrobromide on Odor Detection Performance of Rats. Chemical. Senses 28: 761-765.

Lin, W. et al. Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system. J Neurosci. 2004 24:3703-3710

Lehmkuhle, M.J. et al. 2003 high-resolution analysis of the spatio-temporal activity patterns in rat olfactory bulb evoked by enantiomer odors. Chem. Senses 28: 499-508,

Kraemer, S. and Apfelbach, R. Olfactory sensitivity, learning and cognition in young adult and aged male Wistar rats. Physiol Behav. 2004 81:435-42.

Vedin, V. et al. Zonal ablation of the olfactory sensory neuroepithelium of the mouse: effects on odorant detection Eur J Neurosci. 2004 , 7:1858-64.

Wersinger SR et al. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Hormones and Behav. 46:638-645, 2004

Joly M. et al.Odor discrimination assessment with an automated olfactometric method in a prosimian primate, Microcebus murinus. Physiol Behav. 2004 82(2-3):325-329.

Meyer, B.R. . et al. Monosodium glutamate and sweet taste: discrimination between the tastes of sweet stimuli and glutamate in rats. Chem. Senses 2004 29: 721-729
Abraham, NM et al. Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice. Neuron 44: 744-747, 2004.
Lim, S. et al. Lead Exposure and (n-3) Fatty Acid Deficiency during Rat Neonatal Development Affect Subsequent Spatial Task Performance and Olfactory Discrimination1 J. Nutr. 135:1019-1026, 2005

Joly, M, et al. Age effect on olfactory discrimination in a non-human primate, Microcebus murinus. Neurobiol Aging. 2006, 27:1045-1049

Delay, E.R et al. Glutamate taste: Discrimination between the tastes of glutamate agonists and monosodium glutamate in rats. Chem. Senses 2004 29: 291-299.

Meyer, B.R. . et al. Monosodium glutamate and sweet taste: discrimination between the tastes of sweet stimuli and glutamate in rats. Chem. Senses 2004 29: 721-729.

Taylor-Burds, CC et al. Behavioral comparisons of the tastes of L-alanine and monosodium glutamate in rats. Chem Senses. 2004, 29:807-814.

Slotnick, B.,et al. Olfaction in olfactory bulbectomized rats. J. Neurosci. 2004 249195-19200.

Hayer, BR et al. Monosodium glutamate and sweet taste: discrimination between the tastes of sweet stimuli and glutamate in rats. Chem Senses. 2004 29:721-729.

Salcedo, E. et al. Analysis of Training-Induced Changes in Ethyl Acetate Odor Maps Using a New Computational Tool to Map the Glomerular Layer of the Olfactory Bulb. Chem Senses. 2005, 30:615-629.

Shimshek et al. Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors. PLoS Biology 2005, e354.

Laska, M. et al. Detecting danger—or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals . Physiology and Behavior, 2005, 84:211-215.

Slotnick, B and Restrepo, D. Olfactometry with Mice. Current Protocols in Neuroscience, Unit 8.20. Wiley InterScience, 2005.

Lim, s. et al. Lead Exposure and (n-3) Fatty Acid Deficiency during Rat Neonatal Development Affect Subsequent Spatial Task Performance and Olfactory Discrimination J. Nutr., May 1, 2005; 135(5): 1019 - 1026.

Clevenger, AC and Restrepo D. (2006) Likelihood adaptive staircase procedure for measurement of olfactory detection threshold in mice. Chem. Senses 31:9-26.

Delay, E et al. Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice. Chemical Senses, 2006 31:351-357.

Wesson, DW et al. Enhanced urinary odor discrimination in female aromatase knockout (ArKO) mice. Horm Behav. 2006 49:580-6.

Pho, V et al. Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice. Behav Brain Res. 2005;161:245-53.

Josi, D. et al. Olfactory Sensitivity for Enantiomers and Their Racemic Mixtures--A Comparative Study in CD-1 Mice and Spider Monkeys Chem. Senses 2006 31: 655-664.

Weiler, E et al. Combined Behavioral and c-Fos Studies Elucidate the Vital Role of Sodium for Odor Detection Chem. Senses 2006 31: 641-647.

McBride K and Slotnick, B. Discrimination Between the Enantiomers of Carvone and of Terpinen-4-ol Odorants in Normal Rats and Those with Lesions of the Olfactory Bulbs. J. Neuroscience, 2006, 26:9892-9901.

Laska, M et al. Detecting danger—or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals 2005, Physiol & Behav. 84:211-215.

Alonso, M et al. Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb. J. Neurosci. 2006, 26:10508-10513.

Laska, M and Shepherd, G. (2007)Olfactory discrimination ability of CD-1 mice for a large array of enantiomers, Neuroscience, 144: 295-301.

Wersinger, SR et al. Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2006 Nov 3;
[Epub ahead of print]

Fedorova, I and Salem, N. Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot Essent Fatty Acids. 2006 75:271-289.

Rinberg, D et al. Speed-accuracy tradeoff in olfaction. Neuron. 2006 51:351-358.

Slotnick, B. Olfactory Performance of Rats after Selective Deafferentation of the Olfactory Bulb by 3-Methyl Indole. Chem Senses. 2007 32: 173-181.

Sokolic, A et al. Asymmetric Suppression of Components in Binary Aldehyde Mixtures: Behavioral Studies in the Laboratory Rat. Chem. Senses 2007 32: 191-199.

Wifall, TC et al. An Analysis of 5'-Inosine and 5'-Guanosine Monophosphate Taste in Rats. Chem. Senses 2007 32: 161-172.

Slotnick,B et.al.. Olfaction and olfactory epithelium in mice treated with zinc gluconate. Laryngoscope, 2007, 117:743-749.

Slotnick, B. Olfactory performance of rats after selective olfactory bulb deafferentation by 3-methyl indole. 2007, 32: 173-181.

Slotnick, B Odor-Sampling Time of Mice under Different Conditions 2007 Chemical Senses Chem. Senses 2007 32: 445-454.

Slotnick, B. Response Accuracy and Odor Sampling Time in Mice Trained to Discriminate between Enantiomers of Carvone and those of Terpinen-4-ol Chemical Senses 2007, 32:721-725.

Smith, DW et al. Mice lacking KNCC1 have normal olfactory sensitivity. Physiol.& Behav. 2007. Epub

Waggener, CT and Coppola, DM. Naris occlusion alters the electro-olfactogram: Evidence for compensatory plasticity in the olfactory system. Neurosci. Lett. 2007, 427: 112-116.

Doucette, W. et al. Adrenergic modulation of olfactory bulb circuitry affects odor discrimination. Learning and Memory, 2007. 14:539-547.

Wersinger, SR et al. Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. 2007, Genes Brain Behav. 6:540-541.

Mouret, A et al. (2008) Learning and survival of newly generated neurons: when time matters. J. Neurosci. 28: 11511-11516.

Laska M. et al. 2008 Olfactory discrimination of aliphatic odorants at 1 ppm: too easy for CD-1 mice to show odor structure-activity relationships? J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008 194:971-980.

Wesson DW et al. 2008 Sniffing behavior of mice during performance in odor-guided tasks Chem Senses. ;33:581-596.

Doucette, W and Restrepo, D Profound context-dependent plasticity of mitral cell response in olfactory bulb. PLoS Biology, 6:2266-2285